Runewords are among the most potent items you can create within Diablo 2: Resurrected, although they require quite a bit of work to D2R Items achieve. It is first necessary to locate the right runes to make the runeword. Next, you'll need to find the right weapon, shield, or armor that can accept the runeword. The item should have the exact number of open sockets in order for the runewords to function, and the runes should be placed into the item that is socketed in the appropriate order. The item should also be unadorned (white) as well as magic (blue), rare (yellow) exclusive (gold), and also set (green) items with sufficient sockets won't function for runewords.
For this reason, you should take extra care when creating a runeword. Double- and triple-check that the item's form is correct- for example the Insight runeword may be created using staves and polearms but not spears -- and arrange the runes in the correct sequence before inserting them into the item.
There are many nuances when it comes to weapons and armor that you should make note of. "Body armor" can only be defined as items placed on your body. General "armor" includes shields, boots, gloves, helms, etc. Hammers will not work with runewords intended for maces. "Melee weapons" are not included in ranged weapons, like archery and crossbows. Orbs are also not melee weapons.
When creating runewords have variable stats that determine the quality of the roll you've come up with. A well-constructed runeword roll is always worth a lot better than a poorly constructed roll. Similar to that using the finest runeword base (an item that has sockets) possible is always recommended. For example, if you're creating a runeword to equip on a mercenary, always make use of an Ethereal base. Mercenary weapons and armor don't get less durable, so you'll be able to cheap D2R ladder items get the stat boost from the Ethereal property without worrying about it breaking. Every little boost to stats is counted in Diablo 2: Resurrected.